Immunization-elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

While neutralizing antibodies are highly effective against ebolavirus infections, current experimental ebolavirus vaccines primarily elicit species-specific antibody responses. Here we describe an immunization-elicited macaque antibody (CA45) that clamps the internal fusion loop with the N-terminus...

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Veröffentlicht in:Cell
Hauptverfasser: Zhao, Xuelian, Howell, Katie A., He, Shihua, Brannan, Jennifer M., Wec, Anna Z., Davidson, Edgar, Turner, Hannah L., Chiang, Chi-I, Lei, Lin, Fels, J. Maximilian, Vu, Hong, Shulenin, Sergey, Turonis, Ashley N., Kuehne, Ana I., Liu, Guodong, Ta, Mi, Wang, Yimeng, Sundling, Christopher, Xiao, Yongli, Spence, Jennifer S., Doranz, Benjamin J., Holtsberg, Frederick W., Ward, Andrew B., Chandran, Kartik, Dye, John M., Qiu, Xiangguo, Li, Yuxing, Aman, M. Javad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803079/
https://ncbi.nlm.nih.gov/pubmed/28525756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.04.038
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