Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase

Heparan Sulfate (HS) is a cell signaling molecule linked to pathological processes ranging from cancer to viral entry, yet fundamental aspects of its biosynthesis remain incompletely understood. Here, the binding preferences of the uronyl 2-O-sulfotransferase (HS2ST) are examined with variably-sulfa...

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Udgivet i:Sci Rep
Main Authors: Thieker, David F., Xu, Yongmei, Chapla, Digantkumar, Nora, Chelsea, Qiu, Hong, Felix, Thomas, Wang, Lianchun, Moremen, Kelley W., Liu, Jian, Esko, Jeffrey D., Woods, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081452/
https://ncbi.nlm.nih.gov/pubmed/30087361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29602-4
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