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Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate

Heparan sulfate (HS) is a highly sulfated polysaccharide that plays important physiological roles. The biosynthesis of HS involves a series of enzymes, including glycosyltransferases (or HS polymerase), epimerase, and sulfotransferases. N-Deacetylase/N-Sulfotransferase isoform 1 (NDST-1) is a critic...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dou, Wenfang, Xu, Yongmei, Pagadala, Vijayakanth, Pedersen, Lars C., Liu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536448/
https://ncbi.nlm.nih.gov/pubmed/26109066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664409
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