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Engineering Sulfotransferases to Modify Heparan Sulfate
The biosynthesis of heparan sulfate (HS), an essential glycan in many organisms, involves an array of specialized sulfotransferases. Here, we present a study aimed at engineering the substrate specificity of different HS 3-O-sulfotransferase isoforms. Based on the crystal structures, we identified a...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676843/ https://ncbi.nlm.nih.gov/pubmed/18223645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.66 |
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