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Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis
Heparan sulfate (HS) is a polysaccharide involved in essential physiological functions from regulating cell growth to blood coagulation. HS biosynthesis involves multiple specialized sulfotransferases such as 2-O-sulfotransferase (2OST) that transfers the sulfo group to the 2-OH position of iduronic...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596202/ https://ncbi.nlm.nih.gov/pubmed/19022906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806975105 |
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