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Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis

Heparan sulfate (HS) is a polysaccharide involved in essential physiological functions from regulating cell growth to blood coagulation. HS biosynthesis involves multiple specialized sulfotransferases such as 2-O-sulfotransferase (2OST) that transfers the sulfo group to the 2-OH position of iduronic...

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Hlavní autoři: Bethea, Heather N., Xu, Ding, Liu, Jian, Pedersen, Lars C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596202/
https://ncbi.nlm.nih.gov/pubmed/19022906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806975105
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