T Cell Exhaustion Signatures Vary with Tumor Type and are Severe in Glioblastoma

PURPOSE: T cell dysfunction is a hallmark of GBM. While anergy and tolerance have been well characterized, T cell exhaustion remains relatively unexplored. Exhaustion, characterized in part by the upregulation of multiple immune checkpoints, is a known contributor to failures amidst immune checkpoin...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Woroniecka, Karolina, Chongsathidkiet, Pakawat, Rhodin, Kristen, Kemeny, Hanna, Dechant, Cosette, Farber, S. Harrison, Elsamadicy, Aladine A., Cui, Xiuyu, Koyama, Shohei, Jackson, Christina, Hansen, Landon J., Johanns, Tanner M., Sanchez-Perez, Luis, Chandramohan, Vidyalakshmi, Yu, Yen-Rei Andrea, Bigner, Darell D., Giles, Amber, Healy, Patrick, Dranoff, Glenn, Weinhold, Kent J., Dunn, Gavin P., Fecci, Peter E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081269/
https://ncbi.nlm.nih.gov/pubmed/29437767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1846
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