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IMMU-27. PREVENTING T-CELL S1P1 INTERNALIZATION OBVIATES BONE MARROW T CELL SEQUESTRATION AND IMPROVES IMMUNOTHERAPEUTIC EFFICACY IN GBM
INTRO: Glioblastoma (GBM) is among the most immunosuppressive of solid tumors, eliciting profound lymphopenia and T-cell dysfunction that limit immunotherapeutic success. This lymphopenia, as well as marked lymphoid organ contraction, is recapitulated in murine models of GBM. The bone marrow is the...
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| Publié dans: | Neuro Oncol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216235/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.530 |
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