IMMU-27. PREVENTING T-CELL S1P1 INTERNALIZATION OBVIATES BONE MARROW T CELL SEQUESTRATION AND IMPROVES IMMUNOTHERAPEUTIC EFFICACY IN GBM

INTRO: Glioblastoma (GBM) is among the most immunosuppressive of solid tumors, eliciting profound lymphopenia and T-cell dysfunction that limit immunotherapeutic success. This lymphopenia, as well as marked lymphoid organ contraction, is recapitulated in murine models of GBM. The bone marrow is the...

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Publicado no:Neuro Oncol
Main Authors: Chongsathidkiet, Pakawat, Woroniecka, Karolina, Dechant, Cosette, Kemeny, Hanna, Cui, Xiuyu, Wilkinson, Daniel, Fecci, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216235/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.530
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