Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition

Intranasal insulin has shown effficacy in patients with Alzheimer’s disease (AD), but there are no preclinical studies determining whether or how it reaches the brain. Here, we showed that insulin applied at the level of the cribriform plate via the nasal route quickly distributed throughout the bra...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Salameh, Therese S., Bullock, Kristin M., Hujoel, Isabel A, Niehoff, Michael L., Wolden-Hanson, Tami, Kim, Junghyun, Morley, John E., Farr, Susan A., Banks, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080853/
https://ncbi.nlm.nih.gov/pubmed/26401706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-150307
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