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Intranasal Administration of PACAP: Uptake by Brain and Brain Region Targeting with Cyclodextrins
Pituitary adenylate cyclase activating polypeptide (PACAP) is a potent neurotrophic and neuroprotectant that is transported across the blood-brain barrier in amounts sufficient to affect brain function. However, its short half-life in blood makes it difficult to administer peripherally. Here, we det...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418062/ https://ncbi.nlm.nih.gov/pubmed/22687366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2012.05.021 |
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