miR-145-5p Increases Osteoclast Numbers In Vitro and Aggravates Bone Erosion in Collagen-Induced Arthritis by Targeting Osteoprotegerin

BACKGROUND: Osteoprotegerin (OPG) inhibits bone resorption and binds with strong affinity to receptor activator of NF κB ligand (RANKL), thereby preventing RANKL from binding to its receptor RANK. Osteoclasts have documented effects on bone erosion of rheumatoid arthritis (RA). The aim of this study...

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Publicado en:Med Sci Monit
Autores principales: Chen, Yaqing, Wang, Xiaoxue, Yang, Mengchen, Ruan, Wendong, Wei, Wei, Gu, Dongmei, Wang, Jing, Guo, Xinling, Guo, Lingxia, Yuan, Yuhua
Formato: Artigo
Lenguaje:Inglês
Publicado: International Scientific Literature, Inc. 2018
Materias:
Lab/In Vitro Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080580/
https://ncbi.nlm.nih.gov/pubmed/30059491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.908219
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