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Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
Rearrangement of gene segments to generate antigen receptor coding regions depends on the RAG1/2 recombinase, which assembles a synaptic complex between two DNA signal sequences and then cleaves the DNA directly adjacent to the paired signals. After coupled cleavage of complementary signal sequences...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60801/ https://ncbi.nlm.nih.gov/pubmed/11606753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221471198 |
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