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Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends

Rearrangement of gene segments to generate antigen receptor coding regions depends on the RAG1/2 recombinase, which assembles a synaptic complex between two DNA signal sequences and then cleaves the DNA directly adjacent to the paired signals. After coupled cleavage of complementary signal sequences...

詳細記述

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書誌詳細
主要な著者: Jones, Jessica M., Gellert, Martin
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC60801/
https://ncbi.nlm.nih.gov/pubmed/11606753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221471198
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