Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs

Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment. To overcome these barriers, we developed construc...

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Gepubliceerd in:Cancer Immunol Res
Hoofdauteurs: Dougan, Michael, Ingram, Jessica R., Jeong, Hee-Jin, Mosaheb, Munir M., Bruck, Patrick T., Ali, Lestat, Pishesha, Novalia, Blomberg, Olga, Tyler, Paul M., Servos, Mariah M., Rashidian, Mohammad, Nguyen, Quang-De, von Andrian, Ulrich H., Ploegh, Hidde L., Dougan, Stephanie K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079513/
https://ncbi.nlm.nih.gov/pubmed/29459478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0495
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