Localized CD47 blockade enhances immunotherapy for murine melanoma

CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα). Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular p...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Ingram, Jessica R., Blomberg, Olga S., Sockolosky, Jonathan T., Ali, Lestat, Schmidt, Florian I., Pishesha, Novalia, Espinosa, Camilo, Dougan, Stephanie K., Garcia, K. Christopher, Ploegh, Hidde L., Dougan, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617302/
https://ncbi.nlm.nih.gov/pubmed/28874561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710776114
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