Localized CD47 blockade enhances immunotherapy for murine melanoma

CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα). Inhibitors of the CD47–SIRPα interaction improve antitumor antibody responses by enhancing antibody-dependent cellular p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ingram, Jessica R., Blomberg, Olga S., Sockolosky, Jonathan T., Ali, Lestat, Schmidt, Florian I., Pishesha, Novalia, Espinosa, Camilo, Dougan, Stephanie K., Garcia, K. Christopher, Ploegh, Hidde L., Dougan, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617302/
https://ncbi.nlm.nih.gov/pubmed/28874561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710776114
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