Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs

Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment. To overcome these barriers, we developed construc...

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I publikationen:Cancer Immunol Res
Huvudupphovsmän: Dougan, Michael, Ingram, Jessica R., Jeong, Hee-Jin, Mosaheb, Munir M., Bruck, Patrick T., Ali, Lestat, Pishesha, Novalia, Blomberg, Olga, Tyler, Paul M., Servos, Mariah M., Rashidian, Mohammad, Nguyen, Quang-De, von Andrian, Ulrich H., Ploegh, Hidde L., Dougan, Stephanie K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079513/
https://ncbi.nlm.nih.gov/pubmed/29459478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0495
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