Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs

Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment. To overcome these barriers, we developed construc...

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Xehetasun bibliografikoak
Argitaratua izan da:Cancer Immunol Res
Egile Nagusiak: Dougan, Michael, Ingram, Jessica R., Jeong, Hee-Jin, Mosaheb, Munir M., Bruck, Patrick T., Ali, Lestat, Pishesha, Novalia, Blomberg, Olga, Tyler, Paul M., Servos, Mariah M., Rashidian, Mohammad, Nguyen, Quang-De, von Andrian, Ulrich H., Ploegh, Hidde L., Dougan, Stephanie K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079513/
https://ncbi.nlm.nih.gov/pubmed/29459478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0495
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