Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs

Cytokine-based therapies for cancer have not achieved widespread clinical success because of inherent toxicities. Treatment for pancreatic cancer is limited by the dense stroma that surrounds tumors and by an immunosuppressive tumor microenvironment. To overcome these barriers, we developed construc...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Dougan, Michael, Ingram, Jessica R., Jeong, Hee-Jin, Mosaheb, Munir M., Bruck, Patrick T., Ali, Lestat, Pishesha, Novalia, Blomberg, Olga, Tyler, Paul M., Servos, Mariah M., Rashidian, Mohammad, Nguyen, Quang-De, von Andrian, Ulrich H., Ploegh, Hidde L., Dougan, Stephanie K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079513/
https://ncbi.nlm.nih.gov/pubmed/29459478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0495
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