AND-1 fork protection function prevents fork resection and is essential for proliferation

AND-1/Ctf4 bridges the CMG helicase and DNA polymerase alpha, facilitating replication. Using an inducible degron system in avian cells, we find that AND-1 depletion is incompatible with proliferation, owing to cells accumulating in G2 with activated DNA damage checkpoint. Replication without AND-1...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Abe, Takuya, Kawasumi, Ryotaro, Giannattasio, Michele, Dusi, Sabrina, Yoshimoto, Yui, Miyata, Keiji, Umemura, Koyuki, Hirota, Kouji, Branzei, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079002/
https://ncbi.nlm.nih.gov/pubmed/30082684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05586-7
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