Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites

Warsaw breakage syndrome, a developmental disorder caused by mutations in the DDX11/ChlR1 helicase, shows cellular features of genome instability similar to Fanconi anemia (FA). Here we report that DDX11-deficient avian DT40 cells exhibit interstrand crosslink (ICL)-induced chromatid breakage, with...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Abe, Takuya, Ooka, Masato, Kawasumi, Ryotaro, Miyata, Keiji, Takata, Minoru, Hirota, Kouji, Branzei, Dana
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099846/
https://ncbi.nlm.nih.gov/pubmed/30061412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803110115
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