A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease

Blood erythropoietin (EPO) increases primarily to hypoxia. In sickle cell anaemia (homozygous HBB(E6V); HbSS), plasma EPO is elevated due to hemolytic anaemia-related hypoxia. Hydroxyurea treatment reduces haemolysis and anaemia by increasing foetal haemoglobin, which leads to lower hypoxic transcri...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hum Mol Genet
Egile Nagusiak: Zhang, Xu, Shah, Binal N., Zhang, Wei, Saraf, Santosh L., Miasnikova, Galina, Sergueeva, Adelina, Ammosova, Tatiana, Niu, Xiaomei, Nouraie, Mehdi, Nekhai, Sergei, Castro, Oswaldo, Gladwin, Mark T., Prchal, Josef T., Garcia, Joe G. N., Machado, Roberto F., Gordeuk, Victor R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
Association Studies Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078595/
https://ncbi.nlm.nih.gov/pubmed/28173069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw299
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