A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease

Blood erythropoietin (EPO) increases primarily to hypoxia. In sickle cell anaemia (homozygous HBB(E6V); HbSS), plasma EPO is elevated due to hemolytic anaemia-related hypoxia. Hydroxyurea treatment reduces haemolysis and anaemia by increasing foetal haemoglobin, which leads to lower hypoxic transcri...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Zhang, Xu, Shah, Binal N., Zhang, Wei, Saraf, Santosh L., Miasnikova, Galina, Sergueeva, Adelina, Ammosova, Tatiana, Niu, Xiaomei, Nouraie, Mehdi, Nekhai, Sergei, Castro, Oswaldo, Gladwin, Mark T., Prchal, Josef T., Garcia, Joe G. N., Machado, Roberto F., Gordeuk, Victor R.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Association Studies Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078595/
https://ncbi.nlm.nih.gov/pubmed/28173069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw299
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