Rare cell detection by single cell RNA sequencing as guided by single molecule RNA FISH

Although single cell RNA sequencing can reliably detect large-scale transcriptional programs, it is unclear whether it accurately captures the behavior of individual genes, especially those that express only in rare cells. Here, we use single molecule RNA FISH as a gold standard to assess tradeoffs...

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Bibliografiset tiedot
Julkaisussa:Cell Syst
Päätekijät: Torre, Eduardo, Dueck, Hannah, Shaffer, Sydney, Gospocic, Janko, Gupte, Rohit, Bonasio, Roberto, Kim, Junhyong, Murray, John, Raj, Arjun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078200/
https://ncbi.nlm.nih.gov/pubmed/29454938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.01.014
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