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Rare cell detection by single cell RNA sequencing as guided by single molecule RNA FISH

Although single cell RNA sequencing can reliably detect large-scale transcriptional programs, it is unclear whether it accurately captures the behavior of individual genes, especially those that express only in rare cells. Here, we use single molecule RNA FISH as a gold standard to assess tradeoffs...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Torre, Eduardo, Dueck, Hannah, Shaffer, Sydney, Gospocic, Janko, Gupte, Rohit, Bonasio, Roberto, Kim, Junhyong, Murray, John, Raj, Arjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078200/
https://ncbi.nlm.nih.gov/pubmed/29454938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.01.014
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