Rare cell detection by single cell RNA sequencing as guided by single molecule RNA FISH

Although single cell RNA sequencing can reliably detect large-scale transcriptional programs, it is unclear whether it accurately captures the behavior of individual genes, especially those that express only in rare cells. Here, we use single molecule RNA FISH as a gold standard to assess tradeoffs...

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Pubblicato in:Cell Syst
Autori principali: Torre, Eduardo, Dueck, Hannah, Shaffer, Sydney, Gospocic, Janko, Gupte, Rohit, Bonasio, Roberto, Kim, Junhyong, Murray, John, Raj, Arjun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078200/
https://ncbi.nlm.nih.gov/pubmed/29454938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.01.014
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