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Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

Despite its long history, until now, no receptor has been identified for aspirin, one of the most widely used medicines worldwide. Here we report that peroxisome proliferator-activated receptor alpha (PPARα), a nuclear hormone receptor involved in fatty acid metabolism, serves as a receptor of aspir...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Patel, Dhruv, Roy, Avik, Kundu, Madhuchhanda, Jana, Malabendu, Luan, Chi-Hao, Gonzalez, Frank J., Pahan, Kalipada
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077698/
https://ncbi.nlm.nih.gov/pubmed/30012602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802021115
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