HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

Neurotrophins are important for neuronal health and function. Here, statins, inhibitors of HMG-CoA reductase and cholesterol lowering drugs, were found to stimulate expression of neurotrophins in brain cells independent of the mevalonate pathway. Time-resolved fluorescence resonance energy transfer...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Roy, Avik, Jana, Malabendu, Kundu, Madhuchhanda, Corbett, Grant T., Rangaswamy, Suresh B., Mishra, Rama K., Luan, Chi-Hao, Gonzalez, Frank J., Pahan, Kalipada
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4526399/
https://ncbi.nlm.nih.gov/pubmed/26118928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.05.022
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