Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity

RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To gain better insight into the molecular interactions underlying this process, we investigated FUS, which is...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Bogaert, Elke, Boeynaems, Steven, Kato, Masato, Guo, Lin, Caulfield, Thomas R., Steyaert, Jolien, Scheveneels, Wendy, Wilmans, Nathalie, Haeck, Wanda, Hersmus, Nicole, Schymkowitz, Joost, Rousseau, Frederic, Shorter, James, Callaerts, Patrick, Robberecht, Wim, Van Damme, Philip, Van Den Bosch, Ludo
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077250/
https://ncbi.nlm.nih.gov/pubmed/30021151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.070
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