Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling

Despite the wealth of genetic information available, mechanisms underlying pathological effects of disease-associated mutations in components of G protein-coupled receptor (GPCR) signaling cascades remain elusive. In this study, we developed a scalable approach for the functional analysis of clinica...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Masuho, Ikuo, Chavali, Sreenivas, Muntean, Brian S., Skamangas, Nickolas K., Simonyan, Kristina, Patil, Dipak N., Kramer, Grant M., Ozelius, Laurie, Babu, M. Madan, Martemyanov, Kirill A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077248/
https://ncbi.nlm.nih.gov/pubmed/30021154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.080
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