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Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling

The signal transduction by G Protein-Coupled Receptors (GPCRs) is mediated by heterotrimeric G proteins composed from one of the 16 Gα subunits and the inseparable Gβγ complex assembled from a repertoire of 5 Gβ and 12 Gγ subunits. However, the functional role of compositional diversity in Gβγ compl...

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Détails bibliographiques
Publié dans:Cell Syst
Auteurs principaux: Masuho, Ikuo, Skamangas, Nickolas K., Muntean, Brian S., Martemyanov, Kirill A.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068604/
https://ncbi.nlm.nih.gov/pubmed/33667409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2021.02.001
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