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Live cell optical assay for precise characterization of receptors coupling to Gα12

Heterotrimeric G proteins are essential mediators of G Protein-Coupled Receptors (GPCRs) signalling to intracellular effectors. There is a considerable diversity of G protein subunits that channel signals initiated by GPCRs into specific outcomes. In particular, mammalian genomes contain 16 conserve...

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Bibliografiske detaljer
Udgivet i:Basic Clin Pharmacol Toxicol
Main Authors: Masuho, Ikuo, Skamangas, Nickolas K., Martemyanov, Kirill A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764917/
https://ncbi.nlm.nih.gov/pubmed/30916867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.13228
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