GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells

How G protein-coupled receptors (GPCRs) evoke specific biological outcomes while utilizing a limited array of G proteins and effectors is poorly understood, particularly in native cell systems. Here, we examined signaling evoked by muscarinic (M(2)R) and adenosine (A(1)R) receptor activation in the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Anderson, Allison, Masuho, Ikuo, Marron Fernandez de Velasco, Ezequiel, Nakano, Atsushi, Birnbaumer, Lutz, Martemyanov, Kirill A., Wickman, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322085/
https://ncbi.nlm.nih.gov/pubmed/32513692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001270117
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