AAV9-mediated Rbm24 overexpression induces fibrosis in the mouse heart

The RNA-binding protein Rbm24 has recently been identified as a pivotal splicing factor in the developing heart. Loss of Rbm24 in mice disrupts cardiac development by governing a large number of muscle-specific splicing events. Since Rbm24 knockout mice are embryonically lethal, the role of Rbm24 in...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: van den Hoogenhof, Maarten M. G., van der Made, Ingeborg, de Groot, Nina E., Damanafshan, Amin, van Amersfoorth, Shirley C. M., Zentilin, Lorena, Giacca, Mauro, Pinto, Yigal M., Creemers, Esther E.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076270/
https://ncbi.nlm.nih.gov/pubmed/30076363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29552-x
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