Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function

RNA-binding proteins are key regulators of post-transcriptional processes such as alternative splicing and mRNA stabilization. Rbm24 acts as a regulator of alternative splicing in heart and skeletal muscle, and is essential for sarcomere assembly. Homozygous inactivation of Rbm24 in mice disrupts ca...

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Bibliographic Details
Published in:Sci Rep
Main Authors: de Groot, N. E., van den Hoogenhof, M. M. G., Najafi, A., van der Made, I., van der Velden, J., Beqqali, A., Pinto, Y. M., Creemers, E. E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203132/
https://ncbi.nlm.nih.gov/pubmed/32376900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64667-0
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