Terminal Differentiation of Cardiac and Skeletal Myocytes Induces Permissivity to AAV Transduction by Relieving Inhibition Imposed by DNA Damage Response Proteins

Gene therapy vectors based on the adeno-associated virus (AAV) are extremely efficient for gene transfer into post-mitotic cells of heart, muscle, brain, and retina. The reason for their exquisite tropism for these cells has long remained elusive. Here, we show that upon terminal differentiation, ca...

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Detalhes bibliográficos
Main Authors: Lovric, Jasmina, Mano, Miguel, Zentilin, Lorena, Eulalio, Ana, Zacchigna, Serena, Giacca, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493462/
https://ncbi.nlm.nih.gov/pubmed/22850678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.144
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