LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila

Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the primary cause for motor symptoms observed in Parkinson’s disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most commonly linked contributor to familial PD. LRRK2 is suggested to be inv...

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Publicado no:Hum Mol Genet
Main Authors: Marcogliese, Paul C., Abuaish, Sameera, Kabbach, Ghassan, Abdel-Messih, Elizabeth, Seang, Sarah, Li, Gang, Slack, Ruth S., Haque, M. Emdadul, Venderova, Katerina, Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6075539/
https://ncbi.nlm.nih.gov/pubmed/28158614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx030
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