Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain

Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and α-synuclein (α-syn)-containing inclusions (Lewy bodies), dystrophic dopamine (DA) terminals, and degeneration of midbrain DA neurons. The precise molecular mechanisms underlying these pathological feature...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Friedman, Lauren G., Lachenmayer, M. Lenard, Wang, Jing, He, Liqiang, Poulose, Shibu M., Komatsu, Masaaki, Holstein, Gay R., Yue, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382107/
https://ncbi.nlm.nih.gov/pubmed/22649237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5809-11.2012
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados