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Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

A quantitative analysis of dose–response relationships is essential in preclinical and clinical drug development in order to optimize drug efficacy and safety, respectively. However, there is a lack of quantitative understanding about the dynamics of pharmacological drug–target interactions in biolo...

詳細記述

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書誌詳細
出版年:NPJ Syst Biol Appl
主要な著者: Thiel, Christoph, Smit, Ines, Baier, Vanessa, Cordes, Henrik, Fabry, Brigida, Blank, Lars Mathias, Kuepfer, Lars
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072773/
https://ncbi.nlm.nih.gov/pubmed/30083389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41540-018-0062-3
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