Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal (GI) infections. However, the role of macrophage ODC in colonic epithelial-driven inflammation is unknown. Here we investigate cell-specific effects of ODC...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Singh, Kshipra, Coburn, Lori A., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Shi, Chanjuan, Washington, M. Kay, Luis, Paula B., Schneider, Claus, Delgado, Alberto G., Piazuelo, M. Blanca, Cleveland, John L., Gobert, Alain P., Wilson, Keith T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072585/
https://ncbi.nlm.nih.gov/pubmed/29853605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0116
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