Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal (GI) infections. However, the role of macrophage ODC in colonic epithelial-driven inflammation is unknown. Here we investigate cell-specific effects of ODC...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Res
Prif Awduron: Singh, Kshipra, Coburn, Lori A., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Shi, Chanjuan, Washington, M. Kay, Luis, Paula B., Schneider, Claus, Delgado, Alberto G., Piazuelo, M. Blanca, Cleveland, John L., Gobert, Alain P., Wilson, Keith T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072585/
https://ncbi.nlm.nih.gov/pubmed/29853605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0116
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