Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction

A series of probes with a turn-on switch for the p53–MDM2 protein–protein interaction were developed. After careful evaluation, these small molecule fluorescent probes exhibited high practical activity and selectivity in vitro and in cellulo. In particular probe 10, which had a K(i) value of 0.03 μM...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Liu, Tingting, Jiang, Yan, Liu, Zhenzhen, Li, Jin, Fang, Kun, Zhuang, Chunlin, Du, Lupei, Fang, Hao, Sheng, Chunquan, Li, Minyong
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072338/
https://ncbi.nlm.nih.gov/pubmed/30108877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00287d
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