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Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction
A series of probes with a turn-on switch for the p53–MDM2 protein–protein interaction were developed. After careful evaluation, these small molecule fluorescent probes exhibited high practical activity and selectivity in vitro and in cellulo. In particular probe 10, which had a K(i) value of 0.03 μM...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072338/ https://ncbi.nlm.nih.gov/pubmed/30108877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00287d |
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