Alkyne–azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors via the PI3K/Akt/NF-kB pathway

Herein, we report the isolation and synthetic modification of dehydrozingerone (DHZ, 1), a secondary metabolite present in the rhizome of Zingiber officinale. We synthesized O-propargylated dehydrozingerone, which was subsequently coupled by alkyne–azide cycloaddition (3–20) using click chemistry. T...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Kumar, Chetan, Rasool, Reyaz Ur, Iqra, Zainab, Nalli, Yedukondalu, Dutt, Prabhu, Satti, Naresh K., Sharma, Neha, Gandhi, Sumit G., Goswami, Anindya, Ali, Asif
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072283/
https://ncbi.nlm.nih.gov/pubmed/30108729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00267j
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