Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations

Energy-coupling factor (ECF) transporters are involved in the uptake of micronutrients in bacteria. The transporters capture the substrate by high-affinity binding proteins, the so-called S-components. Here, we present the analysis of two regions of the substrate-binding pocket of the thiamine-speci...

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Vydáno v:Medchemcomm
Hlavní autoři: Swier, L. J. Y. M., Monjas, L., Reeßing, F., Oudshoorn, R. C., Aisyah, Primke, T., Bakker, M. M., van Olst, E., Ritschel, T., Faustino, I., Marrink, S. J., Hirsch, A. K. H., Slotboom, D. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2017
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072235/
https://ncbi.nlm.nih.gov/pubmed/30108823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00079k
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