Electrostatic complementarity within the substrate-binding pocket of trypsin.

The aspartic residue (Asp-189) at the base of the substrate-binding pocket of trypsin was replaced by serine (present in a similar position in chymotrypsin) through site-directed mutagenesis. The wild-type (with Asp-189 in the mature trypsin sequence) and mutant (Ser-189) trypsinogens were expressed...

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Autores principales: Gráf, L, Jancsó, A, Szilágyi, L, Hegyi, G, Pintér, K, Náray-Szabó, G, Hepp, J, Medzihradszky, K, Rutter, W J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1988
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC281667/
https://ncbi.nlm.nih.gov/pubmed/3134655
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