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Mechanism of Parkin activation by PINK1
Mutations in the E3 ubiquitin ligase Parkin (PARK2) and the protein kinase PINK1 (PARK6) are linked to autosomal-recessive juvenile Parkinsonism (AR-JP)1,2, and at the cellular level cause defects in mitophagy, the cellular process that organises destruction of damaged mitochondria3,4. Parkin is aut...
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| Publicado no: | Nature |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071873/ https://ncbi.nlm.nih.gov/pubmed/29995846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0224-x |
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