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Mechanism of phospho-ubiquitin induced PARKIN activation
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy1–3. PINK1 is stabilised on the outside of depolarised mitochondria...
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| Pubblicato in: | Nature |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4984986/ https://ncbi.nlm.nih.gov/pubmed/26161729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14879 |
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