Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH

Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial for adhesion, colonization and infection. Follo...

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Bibliographic Details
Published in:Beilstein J Org Chem
Main Authors: Beiroth, Femke, Koudelka, Tomas, Overath, Thorsten, Knight, Stefan D, Tholey, Andreas, Lindhorst, Thisbe K
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071696/
https://ncbi.nlm.nih.gov/pubmed/30112094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.163
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