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PARP-1–Targeted Radiotherapy in Mouse Models of Glioblastoma
The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damag...
שמור ב:
| הוצא לאור ב: | J Nucl Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Society of Nuclear Medicine
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071508/ https://ncbi.nlm.nih.gov/pubmed/29572254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205054 |
| תגים: |
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