PARP-1–Targeted Radiotherapy in Mouse Models of Glioblastoma

The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damag...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Jannetti, Stephen A., Carlucci, Giuseppe, Carney, Brandon, Kossatz, Susanne, Shenker, Larissa, Carter, Lukas M., Salinas, Beatriz, Brand, Christian, Sadique, Ahmad, Donabedian, Patrick L., Cunanan, Kristen M., Gönen, Mithat, Ponomarev, Vladimir, Zeglis, Brian M., Souweidane, Mark M., Lewis, Jason S., Weber, Wolfgang A., Humm, John L., Reiner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2018
Assuntos:
Theranostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071508/
https://ncbi.nlm.nih.gov/pubmed/29572254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205054
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