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PARP-1–Targeted Radiotherapy in Mouse Models of Glioblastoma
The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damag...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Nucl Med |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Society of Nuclear Medicine
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071508/ https://ncbi.nlm.nih.gov/pubmed/29572254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.117.205054 |
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