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Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA4
Glucokinase (GK) plays a vital role in the control of blood glucose levels and its altered activity can lead to the development of forms of diabetes. We have previously identified a mutant GK (R308K) in patients with type 2 diabetes with reduced enzyme activity. In the present study, the activation...
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| Udgivet i: | FEBS Open Bio |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6070654/ https://ncbi.nlm.nih.gov/pubmed/30087826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12255 |
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