Structural Variations of Human Glucokinase Glu256Lys in MODY2 Condition Using Molecular Dynamics Study

Glucokinase (GK) is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate. The mutations in GK gene influence the affinity for glucose and lead to altered glucose levels in blood causing maturity onset diabetes of the young type 2 (MODY2) condition...

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Main Authors: Yellapu, Nanda Kumar, Kandlapalli, Kalpana, Valasani, Koteswara Rao, Sarma, P. V. G. K., Matcha, Bhaskar
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586473/
https://ncbi.nlm.nih.gov/pubmed/23476789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/264793
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