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Three Novel Mutations I65S, R66S, and G86R Divulge Significant Conformational Variations in the PTB Domain of the IRS1 Gene
[Image: see text] Insulin receptor substrate 1 (IRS1) is one of the major substrates for the IR, and their interaction mediates several downstream insulin signaling pathways. In this study, we have identified three novel mutations in the IRS1 gene of type 2 diabetic (T2D) patients, which reflected i...
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| Publicado en: | ACS Omega |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical Society
2019
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6814177/ https://ncbi.nlm.nih.gov/pubmed/31660472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01712 |
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