Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Excessive cholesterol contributes to the development of cardiovascular diseases. Berberine (BBR) has been reported to regulate cholesterol homeostasis. Here, we found that BBR could ameliorate the hepatic autophagic flux blockade caused by cholesterol overloading. The underlying mechanism included l...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Sun, Haidong, Liu, Qian, Hu, Hai, Jiang, Yisheng, Shao, Wentao, Wang, Qihan, Jiang, Zhaoyan, Gu, Aihua
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070517/
https://ncbi.nlm.nih.gov/pubmed/30068904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0890-5
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